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In the elevated plus-maze, both compounds increased the percentage of time spent in the open arms and decreased the percentage of entries into the closed arm at doses of 1 and 5 mg/kg in mice and at 5 and 10 mg/kg in rats. MDL 73005 was ineffective in mice, while at 5 mg/kg increased the emergence latencies and reduced the number of side-withdrawals. In the emergence test, 8-OH-DPAT reduced the latency to emerge and increased the number of side-withdrawals in mice at doses of 1 and 5 mg/kg, and in rats at doses of 1 and 5 mg/kg and 10 mg/kg. MDL 73005 behaved more potently than 8-OH-DPAT, and at a dose of 1 mg/kg it reduced locomotor activity in mice and rats and increased rearing in mice, while in the open field it was ineffective. At doses of 5 and 10 mg/kg the compound also increased exploratory and grooming behaviors in mice and rats. In the open field, 8-OH-DPAT produced a similar profile of effects in both species: it decreased locomotor activity and reduced spontaneous movement. The behavioral effects of the 5-HT(1A) receptor ligands (+/-)-8-hydroxy-dipropylaminotetralin (8-OH-DPAT) and 1-(4-amino-2-methyl-5-tert-butyl-phenyl)-1,2,3,4-tetrahydro-isoquinoline (MDL 73005) were investigated in mice and rats. 720p.Effects of the anxiolytic properties of serotonin 1A receptor agonists and antagonists.ġ. Wrong Turn 2: Dead End is a 2007 American  .įtv list of girls name Wrong Turn 2 Movie.
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